Juvenile-Onset Inherited Polyneuropathy in Leonberger and Saint Bernard Dogs (LPN1)
This disorder is a severe, juvenile-onset, chronic, progressive, and mixed polyneuropathy, characterised by exercise intolerance, gait abnormalities and muscle atrophy of the pelvic limbs, as well as breathing problems.
The gene responsible has been identified by the research groups of Professor J. Mickelson at the University of Minnesota and Professor C. Drögemüller at Vetsuisse, University of Berne and it is through their kind co-operation that the Animal Health Trust is able to offer the test in the United Kingdom. Further information on the condition can be found on the University of Minnesota Website: (http://www.cvm.umn.edu/vbs/prod/groups/cvm/@pub/@cvm/@vbs/documents/news/cvm_news_211819.pdf) and http://www.cvm.umn.edu/vbs/prod/groups/cvm/@pub/@cvm/@vbs/documents/news/cvm_news_211819.pdf and breeders should read the information there before ordering their test kit.
Breeders using the test will be sent results identifying their dog as belonging to one of three categories:
CLEAR: these dogs have two normal copies of DNA. .
CARRIER: these dogs have one copy of the LPN1 mutation and one normal copy of DNA.
GENETICALLY AFFECTED: these dogs have two copies of the LPN1 mutation
Sampling for the test is by cheek swabs which can be ordered on our Webshop.
Please note that we can only accept samples from the United Kingdom for this test.