DNA Test for Musladin-Lueke Syndrome in Beagles
Musladin-Lueke Syndrome (MLS) is a genetic disorder of Beagles characterised by thick skin and joint contractures. The genetic defect has now been identifed by American researchers in a gene called ADAMTSL2. Breeders will be sent results identifying their dog as belonging to one of three categories:
CLEAR: The dog has 2 copies of the normal gene and will neither develop Musladin-Lueke Syndrome, nor pass a Musladin-Lueke Syndrome gene to its offspring.
CARRIER: The dog has one copy of the normal gene and one copy of the mutant gene that causes Musladin-Lueke Syndrome. It will not develop Musladin-Lueke Syndrome but will, if bred from, pass on the mutant gene to 50% of its offspring, on average.
AFFECTED: The dog has 2 copies of the mutant gene that causes Musladin-Lueke Syndrome and has the disease.
MLS is an autosomal recessive disorder. Crossing the three genotypes - clear, carrier or affected - will produce the following litters:
|clear x clear||all clear|
|clear x carrier||approximately 50% clear 50% carriers|
|clear x affected||all carriers|
|carrier x carrier||approximately 25% clear, 50% carriers 25% affected|
|carrier x affected||approximately 50% clear 50% affecteds|
|affected x affected||all affecteds|
Tests can be ordered through our Webshop http://www.ahtdnatesting.co.uk.