DNA Test for Neuronal Ceroid Lipofuscinosis in Tibetan Terriers
Neuronal Ceroid Lipofuscinosis (NCL) is a neurodegenerative genetic disorder of Tibetan Terriers.
Breeders will be sent results identifying their dog as belonging to one of three categories:
CLEAR: The dog has 2 copies of the normal gene and will neither develop neuronal ceroid lipofuscinosis, nor pass a neuronal ceroid lipofuscinosis gene to its offspring.
CARRIER: The dog has one copy of the normal gene and one copy of the mutant gene that causes neuronal ceroid lipofuscinosis. It will not develop neuronal ceroid lipofuscinosis but will, if bred from, pass on the mutant gene to, on average, 50% of its offspring.
AFFECTED: The dog has 2 copies of the mutant gene that causes neuronal ceroid lipofuscinosis and will develop the disease.
NCL in Tibetan Terriers is an autosomal recessive disorder. Crossing the three genotypes - clear, carrier or affected - will produce the following litters:
|clear x clear||all clear|
|clear x carrier||approximately 50% clear 50% carriers|
|clear x affected||all carriers|
|carrier x carrier||approximately 25% clear, 50% carriers 25% affected|
|carrier x affected||approximately 50% clear 50% affecteds|
|affected x affected||all affecteds|
Tests can be ordered through our Webshop http://www.ahtdnatesting.co.uk.